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(2) Yamazoe
84 SMILES Cl
It is often used as a building block for developing fluoresceinated bioconjugates
Compared with regular HaloTag Ligand
Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-PNP tamra (2) YamazoeSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating
