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Azide-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:5mg RSC Chemical Biology

SKU 84429146637
4.2
USD445.00 USD474.00

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Description

RSC Chemical Biology

Azidoacyl-CA CAS Number Related CAS Molecular Formula C12H23ClN4O3 Molecular Weight 306

Product Name DOTA-NHS Synonyms CAS Number 170908-81-3 Related CAS Molecular Formula C20H31N5O10 Molecular Weight 501

535-542 Donovan

Azide-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:5mg RSC Chemical BiologySOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate

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