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6-ROX is predominantly used to label nucleotides and for DNA sequencing
Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C85H105FN10O21 Molecular Weight 1621
44 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(OCCOCCOCCOCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
75 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:1mg 6-ROX is predominantly used toSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent
