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33 SMILES OCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
It is used to modify amino and hydroxy groups using EDC-mediated couplings when there are difficulties in using 5(6)-TAMRA
NCCC#CC1=CC=C2C(CN(C3CCC(=O)NC3=O)C2=O)=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C41H53N7O16 Molecular Weight 899
Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg 33 SMILES OCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU
