Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg 308 SMILES OCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)

308 SMILES OCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Lenalidomide-PEG5-C2-amine HCl Synonyms Lenalidomide-4'-PEG5-C2-amine HCl CAS Number 2138440-77-2 Related CAS Molecular Formula C25H39ClN4O8 Molecular Weight 559

Product Name Thalidomide-propargyl-O-PEG2-C2-amine HCl Synonyms Thalidomide-4'-propargyl-O-PEG2-C2-amine HCl CAS Number n/a Related CAS Molecular Formula C22H26ClN3O7 Molecular Weight 479

which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins

Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg 308 SMILES OCCC#CC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage