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DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium 47 SMILES OC(=O)CCOCCOCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

SKU 6695453992
4.8
USD445.00 USD480.00

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Description

47 SMILES OC(=O)CCOCCOCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Phthalimidinoglutarimide-C4-Br Synonyms Phthalimidinoglutarimide-4'-C4-Br CAS Number n/a Related CAS Molecular Formula C17H19BrN2O3 Molecular Weight 379

including biomolecules containing azide groups through copper catalyzed azide-alkyne cycloaddition (CuAAC)

Product Name Pomalidomide-5'-C1-acid Synonyms CAS Number 2412056-27-8 Related CAS Molecular Formula C15H13N3O6 Molecular Weight 331

DBCO-Hexanoyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan deuterium 47 SMILES OC(=O)CCOCCOCCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU

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