Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-Exatecan peg2 Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP Synonyms CAS

Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP Synonyms CAS Number Related CAS Molecular Formula C51H73N9O20 Molecular Weight 1132

6-FAM alkyne is an excellent azide-reactive fluorescent reagent for labeling alkyne-containing biological molecules through click chemistry

6 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

8 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCC(O)=O)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-Exatecan peg2 Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I