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It acts as a molecular glue for selective degradation of GSPT1
44 SMILES CC1=CN=C(NC(=O)CC2=CSC(NC3=NC(C)=CC=C3)=N2)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO
CC-647 is a Cereblon modulator
which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins
Mal-Propionyl-Beta-Ala-Val-Cit-PAB(m-PEG8)-MMAE Size:25mg It acts as a molecularSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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