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Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP carboxylic ester a highly potent topoisomerase I

SKU 27269455881
4.4
USD445.00 USD485.00

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Description

a highly potent topoisomerase I inhibitor derived from camptothecin

DOTA bifucational chelator containing an amine group

Product Name Thalidomide-C3-Br Synonyms Thalidomide-4'-C3-Br CAS Number n/a Related CAS Molecular Formula C16H15BrN2O4 Molecular Weight 379

198 SMILES BrCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 90% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-PNP carboxylic ester a highly potent topoisomerase ISOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para

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