Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 378 SMILES C[C@H](NC1=CC=C2C3=NC(=CN3CCOC2=C1)N1[C@@H](COC1=O)C(F)F)C(N)=O Purity (HPLC)

378 SMILES C[C@H](NC1=CC=C2C3=NC(=CN3CCOC2=C1)N1[C@@H](COC1=O)C(F)F)C(N)=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Thalidomide-O-PEG2-C2-acid Synonyms Thalidomide-4'-O-PEG2-C2-acid CAS Number 2488752-64-1 Related CAS Molecular Formula C20H22N2O9 Molecular Weight 434

62 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

707 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 378 SMILES C[C@H](NC1=CC=C2C3=NC(=CN3CCOC2=C1)N1[C@@H](COC1=O)C(F)F)C(N)=O Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I