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068 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
It induces degradation of SALL4 (ZF2)
a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility
high sensitivity (detecting as little as 48 ng/mL enzyme)
Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan aldehyde 068 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The
