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SiR-NHS is the NHS ester of SiR-6-COOH (652Ex/674Em) and can be conjugated to amine-containing molecules easily
Compared to earlier iterations
Proteolysis targeting chimera (PROTAC) building block
Product Name Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C72H96FN9O23 Molecular Weight 1474
Mal-Propionyl-PEG2-Val-Ala-PAB(m-PEG8)-MMAE sir SiR-NHS is the NHS esterSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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